New 9,19-cycloartane triterpenoid from the root of Cimicifuga foetida

• 作 者: ZHU Di-Fan NIAN Yin WANG Hai-Yan ZHANG Zhi-Run SONG Yan-Bo LI Rong-Tao QIU Ming-Hua
• 机 构: Faculty of Life Science and Technology, Kunming University of Science and Technology,State Key Labor
• 出 处: Chinese Journal of Natural Medicines
• 发表日期: 2014年04期
• 关键词: triterpenoid acetoxy silica elucidated spectroscopic epoxy DEPT COSY roots spect

AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography(HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes,(3β, 12β, 15α, 24R)-12, 2’-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside(1), actein(2), 23-epi-26-deoxyactein(3), asiaticoside B(4), and 12β-hydroxycimigenol(5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2’ and C-12.

AIM: To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida. METHOD: Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods. RESULTS: Five 9, 19-cycloartane triterpenes, (3β, 12β, 15α, 24R) -12,2’-diacetoxy-24, -dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26- deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida. CONCLUSION: Compound 1 is a new triterpene with two acetoxy groups at C-2 ’and C-12.