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目的:探讨前列地尔加水化综合护理对糖尿病患者冠脉介入造影术后发生造影剂肾病的影响。方法:选取2011年6月-2014年10月在广州市红十字会医院收治的糖尿病合并冠心病并接受冠脉介入术患者102例作为研究对象,采用区组随机化分组分为实验组(51例)和对照组(51例),分别给予前列地尔加水化综合护理及常规护理,并比较两组资料对术后发生造影剂肾病(CIN)的影响情况。结果:两组患者术前及实验组造影前后血肌酐水平差异无统计学意义(P>0.05),实验组冠脉介入术后并发造影剂肾病的发生率为5.88%,明显低于对照组的23.53%,两组比较差异有统计学意义(P<0.05)。结论:前列地尔加水化综合护理能减少糖尿病患者冠脉造影术后造影剂对肾功能的损害,保护肾功能,对减少CIN并发症的发生具有重要意义。
Objective: To investigate the effect of alprostadil plus hydration on angiography nephropathy after coronary angiography in diabetic patients. Methods: From June 2011 to October 2014, 102 patients with diabetes mellitus and coronary artery disease admitted to Guangzhou Red Cross Hospital were enrolled in this study. Randomized block randomized study was divided into experimental group (51 (Control group) and control group (51 cases) were given alprostadil hydration comprehensive care and routine care, and two groups of data on the incidence of contrast-induced nephropathy (CIN). Results: There was no significant difference in serum creatinine between the two groups before and after angiography (P> 0.05). The incidence of contrast-induced nephropathy after PCI in the experimental group was significantly lower than that in the control group 23.53%, the difference between the two groups was statistically significant (P <0.05). CONCLUSION: Alprostadil combined with hydration can reduce the damage of renal function and protect the renal function of contrast media after coronary angiography in patients with diabetes. It is of great significance to reduce the occurrence of CIN complications.