论文部分内容阅读
目的：探讨脑出血与一氧化氮、氧化、脂质过氧化的关系及临床意义。方法：检测98例脑出血患者以及100例健康人血浆一氧化氮（P-NO）、维生素C（P-VC）、维生素E（P-VE）、过氧化脂质（P－LPO）含量、血浆和红细胞超氧化物歧化酶（P-SOD、E-SOD）活性及红细胞过氧化脂质（E－LPO）含量，采用直线回归和相关、逐步回归分析患者病情（临床神经功能缺损程度积分，NDS）和颅内血肿量与上述指标的关系。结果：与对照组比较，患者组的P-NO、P－LPO、E-LPO平均值均显著升高（P＜0．001），P-VC、P-VE、P-SOD、E-SOD平均值均显著降低（P＜0．001）；逐步回归分析发现患者NDS与P-NO、P-VC、E-LPO值相关最为密切，颅内血肿量与P-NO、P-VE、E-LPO值相关最为密切。结论：脑出血患者体内自由基反应病理性加剧，氧化抗氧化平衡严重失调。
Objective: To investigate the relationship between cerebral hemorrhage and nitric oxide, oxidation, lipid peroxidation and its clinical significance. Methods: The levels of plasma nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE) and lipid peroxidation (P-LPO) were measured in 98 patients with cerebral hemorrhage and 100 healthy controls. Plasma and erythrocyte superoxide dismutase (P-SOD, E-SOD) activity and erythrocyte lipid peroxidation (E-LPO) content were analyzed by linear regression and correlation, and stepwise regression analysis was used to analyze the patient’s condition (clinical neurological deficit score, NDS) and intracranial hematoma volume and the above indicators. Results: Compared with the control group, the average values of P-NO, P-LPO and E-LPO were significantly increased (P <0.001) and P-VC, P-VE, P-SOD and E-SOD (P <0.001). The stepwise regression analysis showed that the correlation between NDS and P-NO, P-VC and E-LPO was the most significant -LPO value most closely related. Conclusion: Cerebral hemorrhage in patients with pathological aggravating free radical reaction, a serious imbalance of oxidation and anti-oxidation.