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目的:观察醋酸甲地孕酮在胃肠道肿瘤患者化疗中的应用效果。方法:选取本院2015年12月至2017年1月接诊的胃肠道肿瘤患者100例,将其随机分为观察组与对照组,每组50例。对照组患者进行单纯化疗,观察组患者在化疗前1d开始给予口服甲地孕酮,直至化疗后5d停止服用。对比两组患者的食欲、KPS评分以及化疗相关不良反应。结果:观察组患者骨髓和消化道不良反应、食欲、KPS评分以及体质量改善情况均优于对照组,对比差异显著,具有统计学意义(P<0.05);对照组患者的骨髓抑制发生率及消化道不良反应均高于观察组,对比差异显著,具有统计学意义(P<0.05)。结论:胃肠道肿瘤患者化疗治疗中应用甲地孕酮可有效缓解化疗的不良反应,可提高患者的生活质量、增加食欲,抑制消化道不良反应,值得推广使用。
Objective: To observe the effect of megestrol acetate in the chemotherapy of gastrointestinal cancer patients. Methods: One hundred patients with gastrointestinal cancer admitted from December 2015 to January 2017 in our hospital were randomly divided into observation group and control group, 50 cases in each group. Patients in the control group were treated with chemotherapy alone. Patients in the observation group were given oral megestrol once a day before chemotherapy, and were stopped 5 days after chemotherapy. The appetite, KPS scores, and chemotherapy-related adverse events were compared between the two groups. Results: The bone marrow and digestive tract adverse reactions, appetite, KPS score and body weight improvement in the observation group were better than those in the control group, the difference was significant (P <0.05); the incidence of bone marrow suppression and Gastrointestinal adverse reactions were higher than the observation group, the difference was significant, with statistical significance (P <0.05). Conclusion: The application of megestrol in the chemotherapy of gastrointestinal cancer patients can effectively relieve the adverse reactions of chemotherapy, improve the quality of life of patients, increase the appetite and inhibit the adverse reactions of gastrointestinal tract, which is worth to promote.