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目的 :分析在妊娠中期给予孕妇血清学筛查对于产前诊断和妊娠结局的预测的意义;方法 :对14729例在我院行产检的妊娠中期孕妇行血清学产前筛查,对于其中高风险孕妇行羊水穿刺产前检查,对于存在开放性神经管缺陷的孕妇行多普勒超声检查,同时对所有孕妇进行妊娠结果随访;结果 :14729例孕妇中,共计筛查出高风险孕妇713例。随访结果显示,筛查高风险孕妇不良妊娠结局发生率明显高于筛查低风险孕妇的不良妊娠结局发生率,P<0.05,具有统计学意义;结论 :给予妊娠中期孕妇血清学筛查,能够及早的筛查出胎儿染色体和解剖结构异常等情况,对于不良妊娠结局有着重要的预测意义。
OBJECTIVE: To analyze the significance of serological screening for pregnant women in the second trimester for the prediction of prenatal diagnosis and pregnancy outcome.Methods: Serological prenatal screening was performed in 14,729 middle-term pregnant women undergoing maternity leave in our hospital. Prenatal examination of amniocentesis for pregnant women, Doppler ultrasound examination of pregnant women with open neural tube defects, and follow-up of pregnancy results for all pregnant women; Results: Among 7 729 pregnant women, 713 high-risk pregnant women were screened out. The follow-up results showed that the incidence of adverse pregnancy outcomes in screening high-risk pregnant women was significantly higher than that in screening low-risk pregnant women, P <0.05, with statistical significance.Conclusion: Serological screening for pregnant women in the second trimester can Early screening of fetal chromosomes and anatomical abnormalities, etc., for the outcome of adverse pregnancy has an important prognostic significance.