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目的 系统评价甘氨双唑钠联合放疗治疗原发性食管癌的有效性和安全性.方法 检索EMbase,PubMed,Cochrane Library,维普数据库、中国期刊全文数据库、万方数据库,纳入甘氨双唑钠联合放疗对比单纯放疗治疗原发性食管癌患者的随机对照试验.试验组予以甘氨双唑钠联合放射疗法治疗,对照组予以单纯的放射疗法.用Bey Man5.3软件对完全缓解率、总缓解率、药物不良反应发生率进行Meta分析.结果 共纳入9项随机对照试验,854例受试对象,其中试验组450例,对照组404例.试验组和对照组的完全缓解率分别为54.22％(244例/450例)和28.46％(115例/404例),总缓解率分别为96.44％(434例/450例)和80.41％(324例/404例),差异均有统计学意义(均P＜0.05).试验组和对照组的药物不良反应发生率分别为49.42％(86例/174例)和55.83％(67例/120例),差异无统计学意义(P＞0.05).结论 甘氨双唑钠联合放疗治疗原发性食管癌的临床疗效显著优于单纯放疗.“,”Objective To evaluate the effectiveness of sodium glycididazole combined with radiotherapy in the treatment of esophageal cancer.Methods RCTs were retrieved from EMbase,PubMed,Cochrane Library,CNKI,VIP,Wanfang database.RCTs about sodium glycididazole combined with radiotherapy in the treatment of esophageal cancer were included.The schedule for treatment group was sodium glycididazole combined with radiotherapy,and that for control group was radiotherapy only.The complete remission rate (CR),total remission rate and incidence of adverse reaction were the combined effect amount and they were evaluated by using Rev Man 5.3 statistical software.Results A total of 9 RCTs were included,which involved 854 patients.Meta-analysis showed that odds ratio of esophageal cancer for both treatments group and control group were 54.22％ (244 cases/450 cases) and 28.46％ (115 cases/404 cases) respectively.Toial remission rate for both groups were 96.44％ (434 cases/450 cases) and 80.41％ (324 cases/404 cases),with significant difference (all P ＜ 0.05).The incidences of adverse reactions were 49.42％ (86 cases/174 cases) in treatment group and 55.83％ (67 cases/120 cases) in control group which had no significant difference(P ＞0.05).Conclusion Short-term efficacy of sodium glycididazole combined with radiotherapy was better than that by radiotherapy alone for esophageal cancer.