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门脉高压症引起食道下段及胃底静脉曲张破裂出血,是肝硬化患者主要致死原因,治疗方法较多,现就降低门脉高压的药物概述如下。 1 生长抑素及其衍生物 临床常用有施他宁(人工合成的十四肽生长抑素)和善得定(奥曲肽)(人工合成环八肽生长抑素类似物)两药。该药能选择性地收缩内脏血管,减少肝血流量,降低门脉压力。付氏报告对12只家兔分别用奥曲肽、施他宁、垂体后叶素注射后,其降门脉压最大幅度分别为46.05％、51.15％和33.33％,示前两者明显优于后者,该氏用上述三药临床治疗66例,其中施他宁组12例,
Portal hypertension caused by lower esophageal and gastric variceal bleeding is the main cause of death in patients with cirrhosis, more treatment, now reduce the portal hypertension drugs are summarized below. 1 somatostatin and its derivatives commonly used in clinical clinically Shi Taining (synthetic fourteen peptide somatostatin) and good set (octreotide) (synthetic cyclic octapeptide somatostatin analogues) two drugs. The drug can selectively shrink visceral blood vessels, reduce hepatic blood flow, reduce portal pressure. Fu’s report on 12 rabbits respectively with octreotide, sitatin, vasopressin injection, the maximum reduction of portal pressure were 46.05%, 51.15% and 33.33% respectively, showing the first two were significantly better than the latter , The use of the clinical treatment of the three drugs 66 cases, including Shi Taining group of 12 cases,