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目的观察138例宫颈电切术(LEEP)病检标本,探讨其病理诊断,分析LEEP手术对病理诊断的影响。方法对138例LEEP病检标本进行病理学观察,应用免疫组织化学Envision法检测P16、PCNA、Ki67的表达。结果 138例宫颈LEEP病检标本中,70例慢性宫颈炎经免疫组织化学检测,8例为宫颈上皮内瘤变(CIN)1级、1例为CIN2级。68例CIN病变中经免疫组织化学检测2例未发现上皮内瘤变。结论宫颈LEEP术后病检标本,可常规选用免疫组化P16、PCNA、Ki67染色,能有效避免因LEEP热效应所致的漏诊和过度诊断。
Objective To observe the pathological changes of 138 cases of LEEP and analyze the influence of LEEP on pathological diagnosis. Methods 138 cases of LEEP disease pathological examination, immunohistochemistry Envision assay P16, PCNA, Ki67 expression. Results In 138 cases of cervical LEEP, 70 cases of chronic cervicitis were detected by immunohistochemistry, 8 cases were grade 1 cervical intraepithelial neoplasia (CIN) and 1 case was grade CIN2. 68 cases of CIN lesions detected by immunohistochemistry in 2 cases did not find intraepithelial neoplasia. Conclusion Cervical LEEP postoperative pathological examination specimens routinely selected immunohistochemistry P16, PCNA, Ki67 staining, can effectively avoid the LEEP thermal effects caused by missed diagnosis and over diagnosis.