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了解北京市通州区1~59岁人群乙型肝炎(乙肝)病毒感染现况,以分析乙肝病毒感染的危险因素。本研究采用多阶段抽样方法,随机抽取1~59岁常住人口628人,进行血清流行病学调查。用雅培微粒子酶免疫分析法检测乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)、乙肝病毒核心抗体(抗-HBc),HBsAg阳性血清检测乙肝病毒e抗原(HBeAg)和乙肝病毒e抗体(-HBe)。采用SPSS 16.0软件对乙肝病毒感染危险因素进行非条件logistic回归分析。结果显示:通州区1~59岁人群HBsAg阳性率为2.07%(95%CI:0.96%~3.18%),抗-HBs阳性率为42.20%(95%CI:38.33%~46.06%),抗-HBc阳性率为15.44%(95%CI:12.62%~18.27%)。标化阳性率分别为3.85%、40.82%、26.59%。15岁以下人群HBsAg阳性率为0.66%(95%CI:0.25%~1.57%),抗-HBs阳性率为46.71%(95%CI:41.10%~52.31%),抗-HBc阳性率为1.64%(95%CI:0.24%~3.04%)。标化阳性率分别为0.57%、47.97%、1.56%。乙肝疫苗接种率为54.78%,标化接种率为23.99%。15岁以下人群接种率为97.37%。拟合多因素回归分析显示乙肝病毒感染危险因素主要是年龄、家庭有乙肝病毒携带者。北京市通州区乙肝感染已由1992年的中度流行区向低度流行区过渡。由于乙肝疫苗广泛接种,15岁以下青少年乙肝病毒感染呈现低感染高保护的特点。应针对乙肝病毒感染的危险因素开展综合防治措施,做好乙肝防控工作。
To understand the status of hepatitis B virus (HBV) infection in people aged 1- 59 in Tongzhou District of Beijing to analyze the risk factors of hepatitis B virus infection. In this study, a multistage sampling method was used to randomly select 628 permanent residents from 1 to 59 years old for serological epidemiological investigation. The HBsAg, HBsAg, HBcAg and HBsAg positive were detected by Abbott microparticle enzyme immunoassay. HBeAg and hepatitis B virus e antibody (-HBe). SPSS 16.0 software was used to analyze the risk factors of hepatitis B virus infection by non-conditional logistic regression. The results showed that the positive rate of HBsAg in Tongzhou district was 59.2% (95% CI: 0.96% -3.18%), the positive rate of anti-HBs was 42.20% (95% CI: 38.33% ~ 46.06% The positive rate of HBc was 15.44% (95% CI: 12.62% ~ 18.27%). The standardized positive rates were 3.85%, 40.82% and 26.59% respectively. The positive rate of anti-HBs was 46.71% (95% CI: 41.10% -52.31%), the positive rate of anti-HBc was 1.64% (95% CI: 0.25% -1.57% (95% CI: 0.24% ~ 3.04%). The standardized positive rates were 0.57%, 47.97% and 1.56% respectively. Hepatitis B vaccination rate was 54.78%, standardized vaccination rate was 23.99%. People under the age of 15 vaccination rate of 97.37%. Fitting multivariate regression analysis showed that the risk factors of hepatitis B virus infection were mainly age and family had hepatitis B virus carriers. Hepatitis B infection in Tongzhou District of Beijing has shifted from the moderate endemic area in 1992 to the endemic area. Due to the widespread inoculation of hepatitis B vaccine, hepatitis B virus infection in adolescents under 15 years of age presents the characteristics of low infection and high protection. Hepatitis B virus infection should be carried out for prevention and treatment of risk factors, prevention and control of hepatitis B do a good job.