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[目的]检测FAP和TGFβ1在宫颈癌中的表达及其意义。[方法]应用免疫组织化学方法对54例宫颈癌进行FAP和TGFβ1的检测。[结果]在54例宫颈癌间质中FAP表达阳性率为88.89%,正常宫颈组织中无表达。FAP表达与宫颈癌的临床分期有关,与淋巴结转移和病理分级无关。在54例宫颈癌组织中,TGFβ1表达阳性率为87.04%。TGFβ1表达与宫颈癌的临床分期和病理分级有关,与淋巴结转移无关。FAP表达与TGFβ1阳性表达呈正相关(r=0.546,P=0.000)。[结论]FAP的表达与宫颈癌演进有关。TGFβ1可诱导癌组织中反应性间质产生,从而促进FAP表达和肿瘤演进。
[Objective] To detect the expression of FAP and TGFβ1 in cervical cancer and its significance. [Method] Immunohistochemistry was used to detect FAP and TGFβ1 in 54 cases of cervical cancer. [Results] The positive rate of FAP expression in 54 cervical cancer stroma was 88.89%, which was not found in normal cervical tissue. FAP expression is related to the clinical stage of cervical cancer, and has nothing to do with lymph node metastasis and pathological grade. In 54 cases of cervical cancer, the positive rate of TGFβ1 expression was 87.04%. The expression of TGFβ1 is correlated with the clinical stage and pathological grade of cervical cancer, but not with lymph node metastasis. FAP expression was positively correlated with TGFβ1 expression (r = 0.546, P = 0.000). [Conclusion] The expression of FAP is related to the progression of cervical cancer. TGFβ1 induces reactive stromal production in cancer tissues, thereby promoting FAP expression and tumor progression.