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目的:探讨亚剂量丙种球蛋白联合激素在小儿特发性血小板减少性紫癜治疗中的应用情况。方法:将唐山市妇幼保健院收治的92例小儿特发性血小板减少性紫癜随机分为两组,对照组45例采用标准剂量丙种球蛋白联合激素治疗,观察组47例采用亚剂量丙种球蛋白联合激素治疗,对两组的临床效果进行比较观察。结果:观察组的总有效率为95.7%,对照组为97.8%,组间差异无统计学意义(P>0.05);观察组的不良反应发生率为2.1%,明显低于对照组(17.8%),组间差异有统计学意义(P<0.05)。结论:亚剂量丙种球蛋白联合激素在小儿特发性血小板减少性紫癜治疗中的应用效果满意,且不良反应少,值得临床关注。
Objective: To investigate the application of sub-dose gammaglobulin combined with hormone in the treatment of idiopathic thrombocytopenic purpura in children. Methods: Ninety-two children with idiopathic thrombocytopenic purpura admitted to Tangshan MCH hospital were randomly divided into two groups. In the control group, 45 patients received standard gamma globulin plus hormone therapy. In the observation group, 47 patients received sub-dose gamma globulin Combined hormone therapy, the clinical effect of the two groups were compared. Results: The total effective rate was 95.7% in the observation group and 97.8% in the control group, with no significant difference between the two groups (P> 0.05). The adverse reaction rate in the observation group was 2.1%, significantly lower than that in the control group (17.8% ), The difference between the groups was statistically significant (P <0.05). Conclusion: The sub-dose of gamma globulin combined with hormone in children with idiopathic thrombocytopenic purpura in the treatment of satisfactory results, and fewer adverse reactions, deserves clinical attention.