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山于化疗和放疗响应用,何杰金氏病(HD)患者生存期明显延长,但由此继发的恶性肿瘤(SM)(?)渐增多。引起人们重视,以往病例分析多针对成年患者,本文作者对320儿童HDSM发病问题进行统计学分析。 320例患者为Sloan-Kcttcring癌症研究中心(MSKCC)1949年至1983年计35年间确诊为HD的患者,年龄者在15岁以下,生存期为1年以上,其中仅254例以前未接受过治疗的患者可做统计学分析。此254例病人可分成两组:一组为仅接受放射治疗或合用单一化疗药物的患者共145例;另一组病人109例接受多种药物联合化疗。自确诊之日,(或治疗开始之日)起1年后发生恶性肿瘤算为SM。 320例病人中共有17例发生SM(其中5例发生于以往接受过治疗的病人),包括急非淋
Hill in response to chemotherapy and radiotherapy, Hodgkin’s disease (HD) patients significantly prolonged survival, but the secondary malignancy (SM) (?) Increasing. Aroused people’s attention, the past case analysis more for adult patients, the author of 320 children with HDSM incidence problems were statistically analyzed. 320 patients were Sloan-Kettcring Cancer Research Center (MSKCC) patients diagnosed with HD for 35 years between 1949 and 1983, under the age of 15, with a survival of over 1 year, of whom only 254 had previously received no treatment Of patients can do statistical analysis. The 254 patients were divided into two groups: a group of patients receiving radiation alone or in combination with a single chemotherapy drug, a total of 145 patients; the other group of 109 patients receiving multiple drug combination chemotherapy. Since the date of diagnosis, (or the date of treatment began) 1 year after the occurrence of malignancy as SM. A total of 17 of 320 patients developed SM (5 of these occurred in previously treated patients), including acute fecal