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结构生物学是一门快速发展的综合性学科,可在原子水平上阐释生命分子之间的组装、相互作用和运动方式,并已逐步应用于寄生虫病研究领域。本文概述了结构生物学的基本研究方法,并以弓形虫棒状体蛋白激酶和钙调蛋白样结构域蛋白酶的结构研究进展为例,综述了结构生物学在弓形虫重要毒力相关因子和药物靶标等研究领域方面的应用和作用。
Structural biology is a rapidly evolving and comprehensive discipline, which can explain the assembly, interaction and movement of life molecules at the atomic level and has been gradually applied in the field of parasitology research. In this paper, the basic research methods of structural biology are summarized. Taking the progresses of the structural studies of Toxoplasma gondii protein kinase and calmodulin-like domain protease as an example, the structural biology of important Toxoplasma virulence related factors and drug targets And other areas of research and application of the role.