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[目的]探讨非贲门胃癌患者诱导型一氧化氮合酶(iNOS)基因多态性与胃癌的易感性的关系.[方法]选取本院2014年4月至2016年4月经胃镜检查或治疗且病理确诊的非贲门胃癌患者80例,设为GC组;选取同期本院经胃镜及病理确诊为胃溃疡(gastric ulcer)的患者88例,设为GU组;另选取同期本院健康体检者140例,设为对照组(C组).通过DNA提取、PCR扩增、时间飞行质谱,比较分析三组iNOS-277位点的基因多态性.[结果]GU组与C组不存在差异(P>0.05);GC组与C组比较存在显著差异(P0.05).iNOS-277 T/T基因型表达是胃溃疡及胃癌发病的独立高危因素.[结论]iNOS基因多态性与胃溃疡及胃癌易感性相关,-277位点T/T基因型是胃溃疡及胃癌发病的独立高危因素.“,”[Objective]To investigate the relationship between inducible nitric oxide synthase (iNOS) gene polymorphism and susceptibility to gastric cancer in patients with non cardia gastric cancer.[Methods] Eighty patients with gastric cardia cancer who were diagnosed by gastroscopy or treated in our hospital from April 2014 to 2016 were enrolled in this study as GC group. 88 cases of gastric ulcer ( gastric ulcer) diagnosed by gastroscope and pathology in our hospital in the same period were selected as GU group; Another 140 healthy persons were selected as control group ( group C) . DNA extraction, PCR amplification, time of flight mass spectrometry were used to analyze the ge-netic polymorphism of iNOS-277 loci of the three groups.[Results]There was no difference between the GU group and the group C ( P>0.05) . There was significant difference between the GC group and the group C ( P0.05) . Expression of iNOS-277 T/T genotype is an inde-pendent risk factor for gastric ulcer and gastric cancer.[Conclusion] iNOS gene polymorphisms is associated with sus-ceptibility to gastric ulcer and gastric cancer. -277 locus T/T genotype is an independent risk factor for gastric ulcer and gastric cancer.