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目的探讨咪唑安定联合芬太尼在无痛人工流产术中的临床疗效。方法选择确诊为早孕并自愿要求行无痛人工流产术者200例,随机分为两组进行麻醉,实验组用咪唑安定加芬太尼,对照组用丙泊酚加芬太尼。详细记录生命体征。结果实验组各项指标围手术期间无明显变化,术中及术后未出现恶心、呕吐。对照组术中与术前相比,收缩压、舒张压、心率均明显下降,两组相比,差异有显著性,(P<0·05)。实验组镇静深度明显不及对照组,而镇痛程度两组无显著差异性。实验组术后恢复较快,无明显不良反应。结论咪唑安定联合芬太尼用于人工流产可达到镇静/镇痛的效果,且副作用小,术中平稳,具备安全有效、恢复迅速等优点,可在临床中广泛应用。
Objective To investigate the clinical efficacy of midazolam combined with fentanyl in painless artificial abortion. Methods A total of 200 cases of painless induced abortion were selected as the first trimester of pregnancy and were randomly divided into two groups for anesthesia. The patients in the experimental group were treated with midazolam plus fentanyl and the control group with propofol plus fentanyl. Detailed record of vital signs. Results The indexes of the experimental group showed no significant changes during the operation, and no nausea and vomiting occurred during and after operation. Compared with preoperative, the systolic blood pressure, diastolic blood pressure and heart rate in the control group were significantly decreased. There was significant difference between the two groups (P <0.05). The sedation depth of the experimental group was significantly lower than that of the control group, while the degree of analgesia was no significant difference between the two groups. Experimental group recovered quickly, no obvious adverse reactions. Conclusion Midazolam combined with fentanyl for sedative / analgesic effect of induced abortion, with fewer side effects, intraoperative stable, safe and effective, and rapid recovery, can be widely used in clinical practice.