论文部分内容阅读
目的比较腹腔镜直肠癌根治术与开腹直肠癌根治术对术后腹腔引流液中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2016年1月至2016年10月60例于济宁医学院附属医院接受手术治疗的直肠癌患者,以回顾性研究方法按手术方式不同将患者分为对照组和腹腔镜组,每组各30例。对照组行开腹直肠癌根治术,腹腔镜组行腹腔镜直肠癌根治术。两组患者均于术前1天抽取肘静脉血,术后1、3、5、7 d上午7时经腹腔引流管自然重力留取腹水送检,采取酶联免疫吸附夹心法测定术前1 d血清及术后1、3、5、7 d腹腔引流液中IL-6、TNF-α的水平。结果两组患者术前1天血清IL-6、TNF-α水平无显著差异(P均>0.05),两组患者术后腹腔引流液IL-6、TNF-α水平均于3 d达高峰,7 d后明显下降。腹腔镜组术后IL-6、TNF-α水平明显低于对照组,差异有统计学意义(P均<0.01)。结论相比于开腹手术,腹腔镜直肠癌根治术术后腹腔引流液中与腹腔粘连相关的炎症因子IL-6、TNF-α水平明显降低,从而能降低术后腹腔粘连发生率。
Objective To compare the effects of laparoscopic radical mastectomy and radical mastectomy on the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in postoperative peritoneal drainage fluid. Methods From January 2016 to October 2016, 60 patients with rectal cancer undergoing surgical treatment in the Affiliated Hospital of Jining Medical College were selected. The patients were divided into control group and laparoscopic group according to the method of retrospective study. 30 cases. Control group underwent open radical resection of rectal cancer, laparoscopic laparoscopic radical resection of rectal cancer. The elbow venous blood was drawn on the 1st day before operation in both groups, and the natural gravities of abdominal drainage tube were taken for ascites inspection at 7:00, 1, 3, 5, 7 d after operation. Enzyme-linked immunosorbent assay d serum and IL-6, TNF-α levels in the peritoneal drainage fluid at 1, 3, 5 and 7 days after operation. Results There was no significant difference in serum IL-6 and TNF-α levels between the two groups (all P> 0.05) one day before operation. The levels of IL-6 and TNF- After 7 d decreased significantly. The levels of IL-6 and TNF-α in laparoscopic group were significantly lower than those in control group (all P <0.01). Conclusions Compared with laparotomy, the levels of inflammatory cytokines IL-6 and TNF-α, which are associated with peritoneal adhesions, in peritoneal drainage fluid after radical operation of laparoscopic radical resection of rectal cancer are significantly lower, which can reduce the incidence of postoperative abdominal adhesions.