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过氧物酶体增殖物激活受体γ(PPARγ)是核受体中的超家族成员,它调控靶基因的转录,参与体内的许多病理生理过程。PPARγ可通过改善胰岛素抵抗,改善糖、脂代谢紊乱,发挥抗动脉粥样硬化作用;还可通过对巨噬细胞的影响,通过抑制炎症反应,抑制平滑肌细胞增殖、迁移,通过对血管内皮功能的影响、调节血管张力等,阻止动脉粥样硬化的形成。PPARγ基因的变异也对动脉粥样硬化有影响。
Peroxisome proliferator-activated receptor γ (PPARγ), a member of the superfamily of nuclear receptors, regulates the transcription of target genes and participates in many pathophysiological processes in the body. PPARy can improve the insulin resistance, improve glucose and lipid metabolism disorders, exert anti-atherosclerotic effect; also by macrophages, by inhibiting the inflammatory response, inhibition of smooth muscle cell proliferation and migration, through the vascular endothelial function Affect the regulation of vascular tone, etc., to prevent the formation of atherosclerosis. Variation of the PPARγ gene also affects atherosclerosis.