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目的前瞻性探讨氯吡格雷抵抗(CR)与临床心脑血管事件(MACCE)的关系。方法对拟诊冠心病患者进行基线检测和随访,对比观察不同基线水平的血小板聚集抑制率(DPAI)值MACCE的发生危险。结果共调查并随访107例心内科住院患者,1年内MACCE发生率为23.8%;CR抵抗者的MACCE发生危险显著升高(OR=3.71,P=0.024),且随着CR水平的升高,MACCE发生危险逐级抬高,差异具有统计学意义(P=0.020)。MACCE组的DPAI值低于未发生MACCE组(14.7%±3.7%vs.27.9%±24.2%;P=0.074)。结论 CR可能是MACCE的一个预测因子。
Objective To investigate the relationship between clopidogrel resistance (CR) and clinical cardiovascular and cerebrovascular events (MACCE). Methods Patients with suspected coronary artery disease were detected and followed up. The risk of MACCE at different baseline levels was evaluated. Results A total of 107 inpatients with cardiology were investigated and followed up. The incidence of MACCE in one year was 23.8%. The risk of MACCE was significantly higher in patients with CR (OR = 3.71, P = 0.024). With the increase of CR, Risk of MACCE increased step by step, the difference was statistically significant (P = 0.020). The DPAI values in the MACCE group were lower than those in the MACCE group (14.7% ± 3.7% vs.27.9% ± 24.2%; P = 0.074). Conclusion CR may be a predictor of MACCE.