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目的:评价盐酸坦索罗辛(tamsulosin)在治疗输尿管下段结石中的临床疗效。方法:160例输尿管下段结石的患者随机分成两组,每组80例。结石直径小于1.0cm。对照组给予左氧氟沙星片(0.2 g,bid);治疗组给予左氧氟沙星(0.2 g,bid)+盐酸坦索罗辛(0.4 mg,qd),每例患者治疗观察期不超过2周。观察结石排出率、结石排出时间、镇痛治疗使用率。结果:2周内结石排出率,对照组为30例(37.5%),治疗组为63例(78.8%),比较差异有统计学意义(P<0.05)。平均排石时间对照组、治疗组分别为(11±3)d、(5±3)d,比较差异有统计学意义(P<0.05)。2周内肾绞痛发作而需镇痛治疗者分别为11例(13.8%)、3例(3.8%),比较差异有统计学意义(P<0.05)。2周内两组均未出现明显副作用,无因不能耐受而退出者。结论:盐酸坦索罗辛在输尿管下段结石的辅助排石方面有效、安全,可明显提高结石的排出率。
Objective: To evaluate the clinical efficacy of tamsulosin in the treatment of lower ureteral calculi. Methods: 160 patients with lower ureteral calculi were randomly divided into two groups, 80 cases in each group. Stone diameter less than 1.0cm. Levofloxacin tablets (0.2 g, bid) were given to the control group. Levofloxacin (0.2 g, bid) and tamsulosin hydrochloride (0.4 mg, qd) were given to the treatment group. The treatment observation period was less than 2 weeks in each patient. Observation of stone discharge rate, stone discharge time, analgesic treatment utilization. Results: The rate of stone excretion in 2 weeks was 30 cases (37.5%) in the control group and 63 cases (78.8%) in the treatment group, the difference was statistically significant (P <0.05). The average time of stone discharging was (11 ± 3) days and (5 ± 3) days in the control group and the treatment group, respectively, with statistical significance (P <0.05). There were 11 cases (13.8%) and 3 cases (3.8%) of renal colic in 2 weeks, respectively. The difference was statistically significant (P <0.05). Two weeks did not show any significant side effects in both groups, no due to can not tolerate and quit. Conclusion: Tamsulosin hydrochloride is effective and safe in the auxiliary row of stones in the lower ureteral calculi, which can significantly improve the rate of stone discharge.