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目的分析急性淋巴细胞性白血病缓解期骨髓幼淋细胞轻度升高(5%～10%)的原因及其临床意义。方法回顾性分析上海儿童医学中心1998年—2005年急性淋巴细胞性白血病缓解期骨髓幼淋细胞轻度升高(5%～10%)的37例患儿,分析其幼淋细胞升高的原因及随访其治疗经过和预后。结果急性淋巴细胞性白血病患儿缓解期骨髓幼淋细胞轻度升高患儿除1例复发以外,其余均缓解。大部分患儿骨髓幼淋细胞升高是化疗后再生的骨髓正常的B系淋巴细胞反应性增生,其中大部分骨髓幼淋细胞可自行恢复正常。另外,病毒感染亦可导致幼淋细胞升高。结论急性淋巴细胞性白血病缓解期骨髓幼淋细胞轻度升高(5%～10%)是骨髓中正常的B系淋巴细胞反应性增生,预后良好。
Objective To analyze the causes and clinical significance of mild lymphocytic leukemia (5% -10%) in acute lymphoblastic leukemia patients during remission period. Methods A retrospective analysis of 37 children with mild lymphocytic leukemia (5% -10%) in Shanghai Children’s Medical Center during 1998-2005 in the remission of acute lymphoblastic leukemia was performed to analyze the causes of the increase of lymphocytic leukemia And follow-up treatment and prognosis. Results In children with acute lymphoblastic leukemia, there was only one case of recurrence except mild lymphocytic leukemia in the remission period. Most of the children with bone marrow infiltration of lymphocytosis is a normal bone marrow regeneration after chemotherapy, B lymphocyte reactive hyperplasia, most of which can be restored to normal. In addition, the virus infection can lead to increased lymphocytes. Conclusions The mild lymphocytic leukemia cells (5% ~ 10%) in remission stage of acute lymphoblastic leukemia are normal B lymphocyte reactive hyperplasia in bone marrow with good prognosis.