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目的比较胺碘酮与琥珀酸美托洛尔合用减少阵发性心房颤动复发的疗效。方法回顾分析42名阵发性心房颤动患者,根据心房颤动复律后维持用药的不同,分为3组:单用胺碘酮组(n=14);单用琥珀酸美托洛尔组(n=14);胺碘酮与琥珀酸美托洛尔合用组(n=14)。比较3组患者用药后12个月中房颤控制情况及心室率、心脏传导情况。结果单用胺碘酮组显效率35.7%,有效率35.7%,无效率28.6%;单用琥珀酸美托洛尔组显效率14.3%,有效率28.6%,无效率57.1%;胺碘酮与琥珀酸美托洛尔合用组显效率78.6%,有效率14.3%,无效率7.14%,其疗效明显优于单用胺碘酮(P<0.05)或单用琥珀酸美托洛尔(P<0.01)组,且未见明显副作用:3组间心室率未见显著差别。结论胺碘酮与琥珀酸美托洛尔合用可有效地控制阵发性心房颤动的发作。
Objective To compare the efficacy of amiodarone and metoprolol succinate in reducing the recurrence of paroxysmal atrial fibrillation. Methods A total of 42 patients with paroxysmal atrial fibrillation were retrospectively analyzed. Patients were divided into three groups according to their maintenance of AF after cardioversion: single amiodarone group (n = 14), single metoprolol succinate group n = 14). Combination of amiodarone and metoprolol succinate (n = 14). Atrial fibrillation control and ventricular rate and cardiac conduction were compared between the three groups after 12 months of treatment. Results The effective rate was 35.7%, the effective rate was 35.7% and the inefficiency rate was 28.6% in the amiodarone alone group. The effective rate was 14.3%, the effective rate was 28.6% and the ineffective rate was 57.1% in metoprolol succinate group alone. Amiodarone and Metoprolol succinate combination group was 78.6% efficient, effective rate of 14.3%, ineffective 7.14%, its efficacy was significantly better than the single amiodarone alone (P <0.05) or metoprolol succinate alone (P < 0.01) group, and no obvious side effects: no significant difference between the three groups ventricular rate. Conclusions Combination of amiodarone and metoprolol succinate can effectively control the onset of paroxysmal atrial fibrillation.