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目的:探讨2型糖尿病眼底增殖改变与冠状动脉病变的关系。方法:对330例2型糖尿病合并冠心病患者进行眼底检测及冠状动脉造影,根据眼底是否具有增殖性改变进行对比分析,并应用多因素分析方法探讨与眼底增殖改变相关的危险因素。结果:2型糖尿病伴眼底增殖改变者,年龄较大,病程较长,尿微量白蛋白阳性检出率增加,TG、TC及HbA1c显著性升高;多支血管病变及钙化病变受累比例增高;Logistic回归分析显示,经调整糖尿病病程、HbA1c、微量白蛋白尿后,2型糖尿病眼底增殖改变仍与冠状动脉钙化相关。结论:2型糖尿病眼底增殖改变与冠状动脉钙化相关。
Objective: To investigate the relationship between the changes of fundus hyperplasia and coronary artery lesions in type 2 diabetic patients. Methods: The fundus examination and coronary angiography were performed in 330 patients with type 2 diabetes mellitus complicated with coronary heart disease. The patients with coronary artery disease were analyzed according to whether the fundus had proliferative changes or not, and the risk factors related to the fundus proliferation were investigated by multivariate analysis. Results: Patients with type 2 diabetes who had changes of fundus fundus, older age, longer course of disease, increased urine microalbumin positive rate, TG, TC and HbA1c were significantly increased; the proportion of multivessel lesion and calcification lesion increased; Logistic regression analysis showed that after adjusting for the course of diabetes, HbA1c and microalbuminuria, the changes of fundus proliferation of type 2 diabetes still correlate with coronary artery calcification. Conclusion: The changes of fundus hyperplasia in type 2 diabetic patients are associated with coronary artery calcification.