论文部分内容阅读
目的采用三维动脉自旋标记(3D-ASL)技术对急性饮酒后早期脑部灌注(CBF)改变进行量化,探讨酒后CBF改变与脑功能之间的联系。方法将80名志愿者分成试验组和对照组,每组40名(男女各20名),平均年龄(25.2±2.7)岁。志愿者均无个人及家族酗酒史、精神药物以及毒品服用史。两组均常规扫描除外脑部病变,试验组空腹服用一定量白酒,对照组空腹服用等量安慰剂,两组在试验前均进行ASL扫描作为基线,随后试验组饮酒后20 min接受ASL扫描,每次检查前均进行生理指标的监测。利用组间t检验分析所得数据。结果试验组21名出现全脑各叶皮层、丘脑、豆状核、小脑、脑桥的CBF增高(P<0.05),所有脑区左右相比差异均无统计学意义(P>0.05),男性的额叶皮质CBF改变最显著。女性则表现为全脑灰质CBF弥漫性增高,各脑区CBF增加程度差异无统计学意义(P>0.05)。11名枕叶、小脑和脑桥CBF出现下降,差异均有统计学意义(P<0.05)。左右脑区相比未发现有CBF改变差异明显的脑区。丘脑与豆状核CBF改变各不相同,差异均无统计学意义。6名脑部CBF与饮酒前基本相同,差异无统计学意义(P>0.05)。2名因饮酒后感到身体明显不适退出试验。整个试验过程中对照组脑部CBF变化差异均无统计学意义。对照组和试验组饮酒前左、右脑区CBF值差异均无统计学意义。结论饮酒后皮质及灰质核团CBF明显升高55.3%(21/38),28.9%(11/38)下降,余15.8%(6/38)变化不明显。说明饮酒能不同程度改变大脑的CBF,尤其是后循环供应的脑区,从而影响脑功能变化。但变化存在明显个体差异,可能是酒后出现不同情绪和执行力差异的重要因素。
Objective To quantify the changes of early cerebral perfusion (CBF) after acute alcohol consumption by three-dimensional arterial spin labeling (3D-ASL), and to explore the relationship between changes of post-operative CBF and brain function. Methods Eighty volunteers were divided into experimental group and control group, 40 in each group (20 males and 20 females), mean age (25.2 ± 2.7) years old. None of the volunteers has a history of personal and family alcohol abuse, psychotropic medications, and drug abuse history. Both groups were routinely scanned except for brain lesions. The experimental group took a certain amount of empty stomach on an empty stomach and the control group took the same amount of placebo on an empty stomach. Both groups were ASL screened before the test as the baseline, then the ASL scans of the test group 20 minutes after drinking, Physiological indicators were monitored before each test. The data obtained were analyzed using intergroup t test. Results There were no significant differences in CBF between all the brain regions (P> 0.05) and CBF (P <0.05) in 21 cortex, thalamus, putamen, cerebellum and pons in the experimental group Frontal cortical CBF changes the most significant. Women showed a diffuse increase in whole brain gray matter CBF, CBF increased in all brain regions showed no significant difference (P> 0.05). Eleven occipital lobe, cerebellar and pontine CBF decreased, the differences were statistically significant (P <0.05). Left and right brain areas compared to no significant changes in CBF brain area. The changes of CBF in thalamus and putamen were different, the difference was not statistically significant. Six brain CBF and alcohol consumption before the same, the difference was not statistically significant (P> 0.05). Two people quit drinking because of obvious physical discomfort after drinking. There was no significant difference in CBF in the control group during the whole experiment. There were no significant differences in CBF between control group and experimental group before drinking left and right brain regions. Conclusions After drinking alcohol, the cortical and gray matter nuclei CBF significantly increased 55.3% (21/38), 28.9% (11/38) decreased, while the remaining 15.8% (6/38) did not change significantly. Shows that drinking can change the brain to varying degrees CBF, especially after the supply of brain area, thus affecting changes in brain function. However, there are obvious individual differences in change, which may be an important factor in the different emotions and executive performances in drinking.