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以硝苯啶片(Ⅱ)为对照,研究了硝苯啶贴片(Ⅰ)对麻醉大鼠血流动力学的影响。结果表明:1(30、10mg/kg皮肤给药)能显著降低麻醉大鼠的收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、左室收缩压(LVSP)和左室压变化速率(±dp/dt_(max)),作用强度与剂量呈正相关。Ⅰ作用强度比Ⅱ(10 mg/kg十二指肠给药)弱,但作用较为平稳、作用维持时间长;Ⅱ可使麻醉大鼠心率(HR)降低,Ⅰ对心率无明显影响(p<0.05)。Ⅰ和Ⅱ对麻醉大鼠左室舒张末期压(LVEDP)、心肌收缩成分缩短速度(V_(CE))的生理最大值(V_(pm))等其它血流动力学指标均无明显影响(P>0.05)。用药后动物心电除P-P间期有不同程度延长外(片剂组p<0.05,贴片组P>0.05,按给药前后自身对照进行比较)亦无明显变化。
The effect of nifedipine patch (Ⅰ) on hemodynamics in anesthetized rats was studied with nifedipine (Ⅱ) as control. The results showed that SBP, DBP, MAP, LVSP and LVSP in anesthetized rats were significantly reduced by 1 (30 and 10 mg / kg) The rate of pressure change (± dp / dt max) was positively correlated with dose. Ⅰ was weaker than Ⅱ (duodenal administration at 10 mg / kg), but the effect was stable and the action was sustained for a long time. Ⅱ reduced the heart rate (HR) of anesthetized rats, and had no significant effect on heart rate (p < 0.05). Ⅰ and Ⅱ had no significant effect on other hemodynamic indexes such as left ventricular end diastolic pressure (LVEDP), physiological maximum (V_ (pm)) of myocardial contractile component (V_ (CE)) in anesthetized rats > 0.05). There was no significant change except for the P-P interval (p <0.05 in the tablet group, P> 0.05 in the patch group and comparison with the self-control before and after administration) after the administration of the drug.