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小肠广泛切除后,由于胰胆分泌物、内分泌激素和食糜的作用,残留肠管粘膜上皮细胞增殖,出现结构性变化。近年来研究发现:改变食糜的组成成分或加入某些特殊物质可以促进短肠综合征(shortbowel snydrome,SBS)残留肠管的代偿性变化,缩短 SBS 患儿完全代偿所需的时间而达到治疗 SBS 的目的。这些特殊物质对正常肠粘膜上皮细胞有明显的营养作用,可改善肠粘膜上皮细胞的代谢,促进细胞的增殖,故统称为肠营养素。本文对近年来肠营养素的研究情况及其在 SBS 治疗中的应用效果作一简要综述。一、谷氨酰胺(glutamine,GLU):谷氨酰胺是一种血液和游离氨基酸池含量最丰富的氨基酸。机体几乎所有组织均能合成 GLU,但骨骼肌是合成和储
After extensive resection of the small intestine, due to the role of pancreaticobiliary secretions, endocrine hormones and chyme, residual intestinal mucosal epithelial cells proliferation, structural changes. In recent years, the study found that: changing the composition of dietary chyme or adding certain special substances can promote the short bowel syndrome (shortbowel snydrome, SBS) residual bowel compensatory change, shorten the time required for complete compensation of SBS children to achieve The purpose of SBS treatment. These special substances on the normal intestinal mucosal epithelial cells have obvious nutritional role, can improve intestinal mucosal epithelial cell metabolism and promote cell proliferation, it is collectively referred to as intestinal nutrients. This article in recent years, intestinal nutrients research and its application in the treatment of SBS made a brief review. First, glutamine (GLU): Glutamine is a blood and free amino acid pool is the most abundant amino acids. GLU can be synthesized in almost all tissues of the body, but skeletal muscle is synthesized and stored