论文部分内容阅读
目的:探讨胎儿颈项皮肤增厚的产前诊断思路和预后分析。方法:对产前超声发现的胎儿颈项皮肤异常增厚孕妇59例进行随访,对比孕妇二联法血清染色体筛查结果、羊水或脐带血穿刺胎儿染色体检查、中晚孕期系统排畸超声检查结果及出生或引产情况。结果:在59例孕妇中,孕11~13+5周颈项透明层增厚胎儿38例,占64.40%,孕≥14周颈后皮褶增厚胎儿21例,占35.60%;发现染色体异常胎儿11例,合并胎儿先天性心脏病7例。胎儿颈项皮肤增厚病例中,使用孕妇血清学筛查21-三体高风险9例(15.25%),18-三体高风险3例(5.08%)。结论:颈部皮肤厚度直接体现胎儿淋巴回流功能,其异常增厚可能由不同的病生理机制引起。产前需结合多项检查并动态观察、分析预后,做出正确的临床诊疗。
Objective: To investigate prenatal diagnosis and prognosis of fetal neck skin thickening. Methods: Fifty-nine pregnant women with premalignant abnormal fetal neck skin abnormalities were followed up. The result of chromosome duplex screening by amniotic fluid or umbilical cord blood biopsy, ultrasonographic examination of middle and late pregnancy Birth or induced abortion. Results: Among the 59 pregnant women, 38 cases (64.40%) had thickened cervical transparent layer during pregnancy from 11 to 13 + 5 weeks, and 21 cases (35.60%) had fetal thickened neck after 14 weeks of gestation. It was found that fetal chromosomal abnormalities 11 cases, 7 cases of fetal congenital heart disease. In the fetal neck skin thickening cases, 9 (15.25%) 21-trisomy high-risk pregnancies and 3 high-risk 18-trisomy (5.08%) were screened by pregnant women. Conclusion: The thickness of neck skin directly reflects the function of fetal lymphatic flow. The abnormal thickening may be caused by different pathophysiological mechanisms. Prenatal combined with a number of checks and dynamic observation, analysis of prognosis, to make the right clinical diagnosis and treatment.