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极化液(Glucose-lnsulin-Kalium-Solu)自1962年Sidi-Pallare等推荐用以治疗心肌梗塞以来,经大量的临床应用和实验研究,已证明其作用机制是:使钾进入细胞内,促进细胞膜极化状态的恢复,以利于心脏的正常收缩。并可抑制心肌缺血时游离脂肪酸的增高,从而改善心脏功能,防止心律失常。虽对疗效评价不一,但已普遍应用于临床,成为治疗急性心梗可供选择的方法之一。为了发挥镁对心脏的治疗作用,1986年我院监护病房在急性心梗的早期治疗中,在GIK中加入25％硫酸镁10m1,称改良后的极化液为GIKM。
Glucose-lnsulin-Kalium-Solu has been used in many clinical and experimental studies since its recommendation for myocardial infarction in 1962 by Sidi-Pallare et al. Recovery of the polarization state of the cell membrane, in order to facilitate the normal contraction of the heart. And can inhibit myocardial ischemia increased free fatty acids, thereby improving cardiac function, prevent arrhythmia. Although the evaluation of different effects, but it has been widely used in clinical practice, as the treatment of acute myocardial infarction is one of the options available. In order to give play to the therapeutic effect of magnesium on the heart, in our hospital intensive care unit in early treatment of acute myocardial infarction in 1986, adding 25% magnesium sulfate 10m1 in GIK, said the modified polarization solution is GIKM.