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急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)占急性髓系白血病的5%～8%,95%以上的患者具有特征性染色体t(15;17)(15q22;17q21),形成早幼粒细胞白血病-维甲酸受体α(PML-RARα)融合基因,并表达PML-RARα融合蛋白。其临床特点是骨髓及血液中有大量早幼粒细胞,易并发
Acute promyelocytic leukemia (APL) accounts for 5% -8% of acute myeloid leukemia. More than 95% of patients have the characteristic chromosome t (15; 17) (15q22; 17q21) Cell leukemia-retinoic acid receptor alpha (PML-RARα) fusion gene and express the PML-RARα fusion protein. Its clinical features are a large number of bone marrow and blood promyelocytic cells, easy to complicated