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目的:观察银翘散对LPS引起的小鼠急性肺损伤治疗作用,并初步探讨其作用机制。方法:健康KM种小鼠气管注入内毒素复制肺损伤模型,分别给予高中低剂量的银翘散。肺部给药24小时后,检测肺组织干湿比值(W/D)、髓过氧化物酶(MPO)和超氧化物歧化酶(SOD)的活力及丙二醛(MDA)含量。结果:与正常对照组相比,急性肺损伤组W/D、MPO和MDA水平均增高(P<0.05),而SOD活力降低(P<0.05);银翘散口服给药组各剂量均能降低急性肺损伤W/D、MPO和MDA水平,提高SOD的活性(P<0.05),且呈剂量依赖关系。结论:银翘散能明显减轻急性肺损伤程度,其作用机制可能与提高肺内抗氧化作用有关。
Objective: To observe the therapeutic effect of Yinqiaosan on LPS-induced acute lung injury in mice and to explore its mechanism. Methods: KM mice were injected intratracheal intratracheal (LPS) -induced lung injury model and were given high, medium and low dose of Yinqiao powder respectively. Twenty-four hours after the lung administration, the ratio of wet / dry ratio (W / D), myeloperoxidase (MPO) and superoxide dismutase (SOD) in the lung tissue and the content of malondialdehyde (MDA) Results: Compared with the normal control group, W / D, MPO and MDA levels in acute lung injury group were significantly increased (P <0.05), and SOD activity was decreased (P <0.05) Reduce W / D, MPO and MDA levels in acute lung injury and increase the activity of SOD (P <0.05) in a dose-dependent manner. Conclusion: Yinqiao Powder can significantly reduce the degree of acute lung injury, and its mechanism may be related to improving the anti-oxidative effect in the lung.