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近年来对肿瘤的形成机制的研究,发现均与基因的变异、缺失、畸形和细胞凋亡受到抑制有关。Survivin是近期发现的凋亡抑制蛋白,是凋亡抑制蛋白家族成员之一,具有抑制细胞凋亡的作用;PTEN是第一个被发现的具有磷酸酯酶活性的抑癌基因,参与细胞生长、增殖、迁移和凋亡过程的调控。研究表明Survivin的过表达和PTEN的失活均与肿瘤的发生发展有关,本文就Survivin和PTEN的分子结构、组织分布、作用机制及应用于膀胱癌发生发展、诊断、预后和治疗上的进展进行综述。
In recent years, the study on the mechanism of tumor formation found that the gene mutation, deletion, deformity and apoptosis were inhibited. Survivin, a recently discovered inhibitor of apoptosis, is a member of the apoptosis-inhibitory protein family and has the effect of inhibiting apoptosis. PTEN is the first tumor suppressor gene with phosphatase activity that is involved in cell growth, Regulation of proliferation, migration and apoptosis. Studies have shown that both overexpression of Survivin and inactivation of PTEN are related to tumorigenesis. The molecular structure, tissue distribution, mechanism of action of Survivin and PTEN and their application in the development, diagnosis, prognosis and treatment of bladder cancer Summary.