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肺部感染、肺不张、肺水肿、肺栓塞、急性呼吸窘迫综合征(ARDS)等肺部并发症是肺叶切除术后最常见的并发症,也是致死的主要原因。研究表明,术后肺损伤是引起肺部并发症的主要原因[1]。胸部手术后肺保护的研究也一直是胸外科的重要研究课题。氨茶碱是临床常用药物,常用于治疗支气管哮喘、慢性阻塞性肺病等,使用安全有效,价格便宜。研究表明,其有效成分茶碱能抑制中性粒细胞黏附毛细血管壁和产生氧自由基,能有效对抗系统性炎症
Pulmonary complications such as pulmonary infection, atelectasis, pulmonary edema, pulmonary embolism, and acute respiratory distress syndrome (ARDS) are the most common complications after lobectomy and are the leading cause of death. Studies have shown that postoperative lung injury is the main cause of pulmonary complications [1]. Lung protection after thoracic surgery has also been an important research topic in thoracic surgery. Aminophylline is a commonly used clinical drug, commonly used in the treatment of bronchial asthma, chronic obstructive pulmonary disease, the use of safe and effective, cheap. Studies have shown that theophylline, an active ingredient, can inhibit the adhesion of neutrophils to the capillary wall and generate oxygen free radicals, which can effectively combat systemic inflammation