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乙肝病毒宫内感染是发展成为乙肝表面抗原慢性携带者的重要原因之一,也是导致出生后接种乙肝疫苗失败的主要原因[1]。我国是乙肝高发区,母婴传播是形成慢性乙肝病毒感染的重要原因,约占我国婴幼儿感染的1/3,人群中慢性乙肝病毒携带者40%～50%是母婴传播造成的。胎儿期乙肝病毒感染,不仅易形成以后慢性乙肝病毒携带状态,且是肝硬化和肝癌的高危因素[2]。我们通过观察母体乙肝病毒感染新生儿脐血T淋巴细胞亚群的变化,了解其免疫功能状态。
Hepatitis B virus intrauterine infection is one of the important reasons for the development of chronic carriers of hepatitis B surface antigen, but also the main reason for the failure of hepatitis B vaccine after birth [1]. China is a high incidence of hepatitis B, mother-to-child transmission is an important cause of the formation of chronic hepatitis B virus infection, accounting for about 1/3 of infants and young children in our country, the population of chronic hepatitis B virus carriers 40% to 50% is caused by mother-to-child transmission. Fetal hepatitis B virus infection, not only easy to form after chronic hepatitis B virus carrying status, and is a high risk of cirrhosis and liver cancer [2]. We observed the status of immune function by observing the changes of T-lymphocyte subsets of cord blood in neonates infected with HBV.