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胃癌作为消化道常见的恶性肿瘤,死亡率较高,患者的预后生存质量与患者的病症分型、肿瘤分型等密切相关,Her2作为Her/erb B家族的活化受体在相关信号转导中起重要的作用,小分子酪氨酸激酶抑制剂、单克隆抗体以及si RNA调节Her2活性。单克隆抗体联合一线的化疗药物对患者进行综合化疗,其对胃癌晚期的患者生存期有显著改善,因此,其分子靶向治疗具有广阔应用前景。
As a common malignant tumor of the digestive tract, gastric cancer has a high mortality rate. The prognosis quality of life of the patients is closely related to the type of the patient’s disease, the type of the tumor, etc. Her2 acts as an activated receptor of the Her / erb B family in the related signal transduction Plays an important role in the regulation of Her2 activity by small molecule tyrosine kinase inhibitors, monoclonal antibodies and si RNA. Monoclonal antibody combined with first-line chemotherapy drugs in patients with integrated chemotherapy, which has a significant improvement in the survival of patients with advanced gastric cancer, therefore, its molecular target therapy has broad application prospects.