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Objective: The purpose of this study was to determine the effectiveness of Mobile-Stroke Risk Scale and Life Style Guidance (M-SRSguide) in promoting a healthy lifestyle and reducing stroke risk factors in atrisk persons.Methods: This research was an clinical trial with a pre-test and post-test control group design.The accessible population is persons at risk of stroke in the community (West and East Kalimantan Province,Indonesia).Thirty-two participants in the intervention group and 32 participants in the control group participated in this study.The sampling method was systematic random sampling.We allocate the sample into the intervention and control groups using a randomized block design.The intervention group used the M-SRSguide.The control group used manual book for a self-assessment of stroke risk.The measurement of a healthy lifestyle and the stroke risk factors was performed before and six months after the intervention.Results: There are no significant differences in healthy lifestyle and stroke risk factors between the two groups after the intervention (P ＞ 0.05).Analysis of healthy lifestyle behavior assessment items in the intervention group showed an increase in healthy diets,activity patterns,and stress control after the use of the M-SRSguide (P ＜ 0.01).Conclusion: The use of M-SRSguide is effective in promoting a healthy lifestyle.