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目的:探讨人肝癌组织中细胞因子信号转导抑制因子-3(SOCS-3)的表达。方法:应用RT-PCR法测定8例人正常肝组织、10例肝硬化组织及10例肝癌组织中SOCS-3mRNA的表达。结果:与正常肝组织和肝硬化相比较,肝癌组织SOCS-3mRNA的表达明显降低(P<0.05)。肝硬化组织与正常肝组织SOCS-3mRNA的表达无明显差异(P>0.05)。结论:SOCS-3表达下降与肝癌的发生、发展密切相关。
Objective: To investigate the expression of cytokine signaling inhibitor-3 (SOCS-3) in human hepatocellular carcinoma. Methods: The expression of SOCS-3 mRNA in 8 human normal liver tissues, 10 liver cirrhosis tissues and 10 liver cancer tissues was detected by RT-PCR. Results: Compared with normal liver tissues and cirrhosis, the expression of SOCS-3 mRNA in hepatocellular carcinoma tissues was significantly decreased (P <0.05). There was no significant difference in the expression of SOCS-3mRNA between cirrhosis and normal liver tissues (P> 0.05). Conclusion: The decreased expression of SOCS-3 is closely related to the occurrence and development of hepatocellular carcinoma.