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目的:探讨双倍剂量泮托拉唑用于治疗重症消化性溃疡上消化道大出血的疗效和副作用。方法:治疗组49例采用泮托拉唑80mg·d~(-1),ivd,对照组45例采用奥美拉唑40 mg ivd,q12h,连续治疗5d。观察两组的止血疗效,输血量和副作用发生情况。结果:治疗组和对照组显效率分别为51.02%和44.44%(P<0.05),总有效率分别为97.96%和86.66%(P<0.05),两组间差异有统计学意义。平均输血量:治疗组为(384.62±137.67)ml,对照组为(580.95±153.68)ml,两组均无明显不良反应发生。结论:双倍剂量泮托拉唑止血效果明显,输血量减少,无明显不良反应。
Objective: To investigate the efficacy and side effects of double-dose pantoprazole in the treatment of upper gastrointestinal bleeding in severe peptic ulcer. Methods: In the treatment group, 49 cases were treated with pantoprazole 80 mg · d ~ (-1), iv and 45 cases in the control group were given omeprazole 40 mg ivd, q12h for 5 days. Hemostatic efficacy, blood transfusion and side effects were observed in both groups. Results: The effective rates of treatment group and control group were 51.02% and 44.44%, respectively (P <0.05). The total effective rates were 97.96% and 86.66% respectively (P <0.05). There was significant difference between the two groups. The mean blood transfusion was (384.62 ± 137.67) ml in the treatment group and (580.95 ± 153.68) ml in the control group, with no obvious adverse reactions in both groups. Conclusion: The double dose of pantoprazole has obvious hemostatic effect, reduced transfusion volume and no obvious adverse reaction.