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对内蒙敖汉旗３个自然村７～１５周岁的青少年进行了１：１配比病例对照研究，测定了８６对骨龄延迟和骨龄正常者饮水氟和血清中锌、铜、钙、镁、镍的含量。统计结果表明：无论男性或女性骨龄延迟者的身高均低于同性别的骨龄正常者；高水氟、高血铜是本地区青海〓少年骨龄延迟的危险因素，与骨龄延迟之间存在剂量—反应关系；水氟和血清铜之间无交互作用。
A 1: 1 matched case-control study was conducted in adolescents aged 7-15 years in 3 natural villages in Aohan Banner, Inner Mongolia. 86 children with normal bone age and normal bone age were tested for fluoride and serum zinc, copper, calcium, magnesium and nickel content. The results showed that both men and women with delayed bone age were lower than those with the same age in normal age group. High fluoride and high blood copper were the risk factors for the delayed bone age in juveniles in this region. However, Reaction relationship; no interaction between water fluoride and serum copper.