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目的探讨肾综合征出血热(HFRS)患者血脂、尿素氮及肌酐含量与患者病情的关系。方法以酶法测定TG、TC、HDL-C含量,免疫扩散法测定apoAI、B100含量,日本CL-7200全自动生化分析仪检测BUN、Cr水平。结果HFRS患者各病期(或病型)血清TG、BUN和Cr含量显著高于对照组,而血清HDL-C、LDL-C以及apoAⅠ水平显著低于对照组,其中以少尿期指标变化更为明显。血清TC含量在不同病期各组组之前差异不大,仅少尿期TC水平较对照组显著降低。重型组患者TC水平显著低于对照组。结论HFRS血清HDL-C、LDL-C、apoAⅠ、TG、BUN、Cr和TC等指标与患者病情密切相关,可作为判断HFRS分期及严重程度的指标。
Objective To investigate the relationship between serum lipid, urea nitrogen and creatinine in patients with hemorrhagic fever with renal syndrome (HFRS). Methods The levels of TG, TC and HDL-C were determined by enzymatic method. The contents of apoAI and B100 were determined by immunodiffusion method. The levels of BUN and Cr were measured by Japan CL-7200 automatic biochemical analyzer. Results The levels of serum TG, BUN and Cr in HFRS patients at different stages of disease (or disease type) were significantly higher than those in control group, while the levels of serum HDL-C, LDL-C and apoAⅠ in HFRS patients were significantly lower than those in control group Obvious. There was no significant difference in serum TC levels between groups before and during the different stages of disease, while the level of TC in the oliguria period was significantly lower than that in the control group. TC level in severe group was significantly lower than that in control group. Conclusion The serum levels of HDL-C, LDL-C, apoAI, TG, BUN, Cr and TC in serum of HFRS are closely related to the patient’s disease, which can be used as an index to judge the stage and severity of HFRS.