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骨髓移植从动物试验到临床应用到现在已有30年。早期的成功率甚低,近十年来,由于免疫学的发展,组织配型技术的应用,免疫抑制和支持疗法的改进,骨髓移植进入新的阶段,今天已成为再生障碍性贫血、放射病、严重免疫缺陷病、白血病及其他某些血液系统疾病的一种有希望疗法。现将有关资料综述如下: 骨髓移植的免疫学问题骨髓移植主要障碍是供者和受者的组织相容性问题。这种障碍,当供者和受者为一卵孪生时,则不成问题。反之,则存在一定程度的
Bone marrow transplantation from animal experiments to clinical application has now been 30 years. The early success rate is very low. In the past ten years, due to the development of immunology, the application of tissue matching technology, the improvement of immunosuppression and supportive therapy, bone marrow transplantation has entered a new stage and today it has become aplastic anemia, radiation sickness, severe Immunodeficiency disease, leukemia and some other hereditary diseases of the blood system. The relevant information is now summarized as follows: Immunological Problems of Bone Marrow Transplantation The main obstacle to bone marrow transplantation is the donor-recipient histocompatibility issue. This obstacle is not a problem when the donor and recipient are twins. On the contrary, there is a certain degree of