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研究了高锶饮水对大鼠骨骼生长发育的影响。结果表明，饮水中锶浓度为５～５００ｍｇ／Ｌ达１２周可引起Ｗｉｓｔａｒ大鼠血清、尿、股骨、颌骨和牙齿中锶含量增高，呈明显的剂量－反应关系。同时，锶还可使骨骼钙含量降低，牙齿钙含量和骨骼的骨密度增高，以及除第１２周雌性大鼠外血清钙水平下降。尚未发现锶对动物体重、体长、血清ＡＫＰ活性、尿钙水平以及股骨弯曲断裂载荷的影响。然而，锶对动物骨骼生长发育影响性别之间存在差异，如在第１２周染锶组雄性大鼠血清钙含量降低，而雌性大鼠升高；在第４周和第８周时，仅雄性大鼠尿Ｈｏｐ／Ｃｒ比值增高，而雌性大鼠维持于正常水平；Ｓｒ２＋还使雄性大鼠颌骨骨密度增加，而雌性大鼠股骨骨密度增加。上述改变提示可能是动物性别之间在内分泌调节和代谢过程上不同的结果。
The effect of high strontium on the growth and development of bone in rats was studied. The results showed that strontium concentration in drinking water of 5 ~ 500mg / L for 12 weeks caused Wistar rats serum, urine, femur, jaw and teeth strontium content increased, showing a dose-response relationship. At the same time, strontium also reduced bone calcium content, increased dental calcium content and bone mineral density, and decreased serum calcium levels except for the 12th week in female rats. The effect of strontium on body weight, body length, serum AKP activity, urinary calcium levels and the bending fracture load of femur has not been found. However, there was a difference in the sex and sex of the growth and development of animal skeletons when strontium was used. For example, the serum calcium level of the strontium-treated male rats decreased in the twelfth week and the female rats increased; in the fourth and eighth weeks, only the male The urinary Hop / Cr ratio increased in rats, while the female rats maintained at normal levels. Sr2 + also increased the mandibular BMD in male rats, while the femoral BMD increased in female rats. The above suggested changes may be the result of differences in the processes of endocrine regulation and metabolism between animal sex.