犬细小病毒单克隆抗体在治疗上的应用研究

来源 :北京实验动物科学与管理 | 被引量 : 0次 | 上传用户:ivantesr
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本试验采用犬细小病毒单克隆抗体(CanineParvovirusMonoclonalAntibody,CPVMcAb)对287例患细小病毒性肠炎的病犬,经股内侧肌肉注射进行治疗,取得令人满意的结果。1.在收治的287例病犬中,治愈279例,治愈率高达97.21%,尤其是小于3月龄的幼犬,治愈率高达97.92%,显著高于其他治疗方法的治疗效果。2.在收冶的287例病犬中,6月龄以下幼犬占93.73%。冬季发病犬占92.68%,说明本病主要发生于6月龄以下幼犬,冬季发病较多,其次为初春或深秋,夏季发病较少。3.在临床治疗中发现,发病一天的病犬仅注射CPVMcAb,而不采取其他对症措施,病犬即可在2天内完全康复。发病3天以内的病犬241只,在注射CPVM_-cAb同时,结合对症措施,治愈24O只,仅死亡1只。随病程延长,治愈率下降。另外,88.53%的治愈犬在注射CPVMcAb4天内完全康复,说明采用CPVMcAb治疗还可缩短病程。4,注射CPVMcAb后7h以内死亡的病犬,主要是由于发病后期,全身性衰竭、肠道广泛性出血、坏死和严重脱水,注射的CPVMcAb未能起作用。3天后死亡的病犬,可能是由于CPVMcAb虽? In this study, Canine Parvovirus Monoclonal Antibody (CPVMcAb) was used to treat 287 dogs with parvovirus enteritis via the intramuscular injection of intramuscular medulla to achieve satisfactory results. 1. Among the 287 dogs treated, 279 cases were cured, the cure rate was as high as 97.21%, especially for puppies less than 3 months old, the cure rate was as high as 97.92%, which was significantly higher than that of other treatment methods. 2. In the collection of 287 cases of dogs, puppies less than 6 months accounted for 93.73%. The number of dogs in winter accounted for 92.68%, indicating that the disease occurs mainly in puppies 6 months old, more incidence in winter, followed by early spring or late autumn, less incidence in summer. 3. In clinical treatment found that the incidence of the day dog ​​only CPVMcAb injection, without taking other symptomatic measures, dogs can be completely recovered within 2 days. 241 cases of sick dogs within 3 days of onset, in the injection of CPVM_-cAb at the same time, with symptomatic measures, healing 24O only one death. With the extended duration, the cure rate decreased. In addition, 88.53% of cures completely recovered within 4 days of CPVMcAb injection, indicating that treatment with CPVMcAb can also shorten the course of the disease. 4, CPVMcAb within 7h after the death of dogs, mainly due to late onset, systemic failure, extensive intestinal bleeding, necrosis and severe dehydration, injection of CPVMcAb failed to play a role. Dogs died after 3 days may be due to CPVMcAb Although?
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