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目的讨论结核感染T细胞斑点试验(T cell spot.tuberculsis,TSPOT.TB)在喉结核患者诊断中的应用效果。方法 2009年1月—2014年4月选择在黑龙江省医院耳鼻喉科检查治疗的60例患者作为研究对象,最终确诊为喉结核患者25例,以喉镜病理诊断为金标准,比较TSPOT.TB和结核菌素(PPD)试验的准确度、灵敏度、特异度及阳性和阴性预测值等指标上的差异。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异具有统计学意义。结果 TSPOT.TB和PPD试验在检测准确率(93.3%、73.3%)、灵敏度(88.0%、64.0%)、阳性预测值(95.7%、69.6%)等方面差异均有统计学意义(χ2=8.640、5.947、5.447,均P<0.05);而在特异度(97.1%、80.0%)和阴性预测值(91.9%、75.7%)方面比较差异均有统计学意义(χ2=3.528、3.581,均P>0.05)。结论 TSPOT.TB具有检查费用低、操作简单易行等特点,同时具有较高的检测准确度、灵敏度、特异度、阳性预测值和阴性预测值,能够对喉结核进行准确和快速的筛查,减轻患者的经济负担,在临床具有较高的应用价值和实用价值。
Objective To discuss the application of T cell spot test (T cell spot test) in the diagnosis of laryngeal tuberculosis. Methods From January 2009 to April 2014, 60 patients with otolaryngology examination and treatment in Heilongjiang Provincial Hospital were selected as the study subjects, and 25 patients with laryngeal tuberculosis were diagnosed finally. Pathological diagnosis of laryngoscope was the gold standard, and TSPOT.TB was compared And tuberculin (PPD) test accuracy, sensitivity, specificity and positive and negative predictive value and other indicators of the differences. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The accuracy of TSPOT.TB and PPD test was statistically significant (93.3%, 73.3%), sensitivity (88.0%, 64.0%) and positive predictive value (95.7%, 69.6% , 5.947,5.447, all P <0.05), while there was significant difference between specificity (97.1%, 80.0%) and negative predictive value (91.9%, 75.7%) (χ2 = 3.528, 3.581, > 0.05). Conclusion TSPOT.TB has the characteristics of low cost, simple and easy operation, high detection accuracy, sensitivity, specificity, positive predictive value and negative predictive value. It can accurately and rapidly detect laryngeal tuberculosis, Reduce the patient’s financial burden, has a high clinical value and practical value.