论文部分内容阅读
目的探讨三维适形放射治疗门脉癌栓的近期疗效。资料与方法 23例均为肝癌介入治疗后出现门静脉癌栓,其中原发性肝癌8例,转移性肝癌15例,所有病人均在介入治疗2～4次后出现门静脉癌栓。采用三维适形照射的方法,每例均设定4～6个非共面野,单次照射剂量3～7Gy,6～15次,每日或隔日照射,总剂量42～48 Gy。结果总有效率3个月为82.6%,6个月为95.7%,Kaplan-Meier分析法,1、2、3年生存率分别为82.6%、43.5%和26.1%,中位生存期14个月。Cox 回归分析提示 Child-Pugh 肝功能分级和单次照射剂量与预后有关。结论三维适形放射治疗肝癌介入后门静脉癌栓是一种方法简单、病人易于接受、近期疗效显著的可行性方法,值得临床推广。
Objective To investigate the short-term curative effect of three-dimensional conformal radiotherapy on portal vein tumor thrombus. Materials and Methods Twenty - three cases of portal vein tumor thrombus occurred after interventional treatment of hepatic cancer, including 8 cases of primary liver cancer and 15 cases of metastatic liver cancer. All patients had portal vein tumor thrombus after interventional treatment for 2 to 4 times. A total of 4 ~ 6 non-coplanar fields were set in each case with three-dimensional conformal irradiation. The dose was 3 Gy, 7 Gy, 6-15 times daily, or daily for a total dose of 42-48 Gy. Results The total effective rate was 82.6% in 3 months and 95.7% in 6 months. The Kaplan-Meier analysis showed that the 1, 2, 3-year survival rates were 82.6%, 43.5% and 26.1% respectively. The median survival time was 14 months . Cox regression analysis showed that Child-Pugh liver function classification and single dose were related to prognosis. Conclusion Three-dimensional conformal radiotherapy for portal vein tumor thrombus after interventional therapy of liver cancer is a simple method, the patient is easy to accept, the short-term curative effect is significant and feasible method, worthy of clinical promotion.