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目的:评价3-7岁儿童乙肝病毒感染状况和抗体水平。方法于1999年、2008年分别采集农七师十个农牧团场有乙肝疫苗免疫接种史的3-7岁儿童血清3083份、3502份,检测抗—HBs(+)和HBsAg(+),并分别计算各年龄组的抗-HBs(+)阳性率和HBsAg(+)阳性率。结果2008年3-7岁儿童抗—HBs(+)阳性率为81.46%,HBsAg(+)阳性率为0.29%。各年龄组抗—HBs(+)阳性率均高于1999年适龄儿童,HBsAg(+)阳性率均低于1999年适龄儿童。结论农七师现行免疫接种程序乙肝疫苗具有良好的免疫效果。农七师3-7岁儿童感染率可有效控制在0.5%以下。
PURPOSE: To evaluate the status of hepatitis B virus infection and antibody levels in 3-7-year-old children. Methods In 1999 and 2008, 3083 and 3502 serum samples from 3-7-year-old children with past history of hepatitis B vaccine immunization were collected from ten farmers and herdsmen’s farms in Nongqijian, Ningxia. The anti-HBs (+) and HBsAg (+ The anti-HBs (+) positive rate and HBsAg (+) positive rate of each age group were calculated respectively. Results The positive rate of anti-HBs (+) in children aged 3-7 years was 81.46% and the positive rate of HBsAg (+) was 0.29% in 2008. The positive rate of anti-HBs (+) in all age groups was higher than that of 1999-year-old children, and the positive rate of HBsAg (+) was lower than that of 1999-year-old children. Conclusion The current immunization program of seven agricultural division of hepatitis B vaccine has a good immune effect. 7-year-old children of seven agricultural division infection rate can be effectively controlled at 0.5%.