【摘 要】
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New work published in Molecular Cell by Fu et al.reveals that the protein kinase ALK1 is deregulated when the enzymes assembling and disassembling Met1-ubiquitination,LUBAC and OTULIN,are inhibited or missing.This latest non-degradative role for ubiquitin
【机 构】
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Ubiquitin Signalling Division,Walter and Eliza Hall Institute of Medical Research,1G Royal Parade,Pa
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New work published in Molecular Cell by Fu et al.reveals that the protein kinase ALK1 is deregulated when the enzymes assembling and disassembling Met1-ubiquitination,LUBAC and OTULIN,are inhibited or missing.This latest non-degradative role for ubiquitin impacts on Smad1/5 signaling and deregulates angiogenesis downstream of bone morpho-genetic proteins,adding to the growing list of Met1-polyubiquitin-regulated cellular pathways.
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