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异名 E-643,E-0643,Detantol 化学名 2-[4-(N-丁酰)高哌嗪-1-基]-4-氨基-6,7-二甲氧基喹唑啉药效分类降压药开发单位 (日)卫材上市厂商 (日)卫材 1985年7月文献 Jap Circul J 1977,41(8):903 药理哌唑嗪是α_1受体阻滞药,与以前的α阻滞药酚托拉明、酚苄明不同,它选择性地阻滞突触后的α_1受体,而不阻滞突触前的α_2受体,故作用持续时间长,血压下降时不引起心率加快,但有时引起直立性低血压,因此在使用时须加注意。本品是α_1受体阻滞
Synonyms E-643, E-0643, Detantol Chemical Name 2- [4- (N-Butyryl) homopiperazin-1-yl] -4-amino-6,7-dimethoxyquinazoline Category Antihypertensives Developer (E) Eisai Listed Company (Eisai) Eisai July 1985 Literature Jap Circul J 1977, 41 (8): 903 Pharmacology Prazosin is an alpha-1 blocker that binds to the previous alpha Blocking drug tranexamine, phenoxybenzamine different, it selectively block post-synaptic α_1 receptor, without blocking the presynaptic α_2 receptor, so the role of long duration, blood pressure does not cause a decline Heart rate, but sometimes caused by orthostatic hypotension, so be careful when in use. This product is α_1 receptor block