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目的观察普罗布考早期治疗对急性冠状动脉综合征(ACS)患者的血管内皮功能的影响。方法49例ACS患者随机分为两组,普罗布考组(P组,n=24)和常规治疗组(C组,n=25),检测外周血氧化低密度脂蛋白(ox-LDL)、一氧化氮(NO)及循环内皮细胞(CEC)数量,应用高频超声测肱动脉内皮依赖血管舒张功能(FMD),用药治疗3个月,观察治疗前后指标变化。结果P组患者治疗后与治疗前相比,外周血中ox-LDL和CEC水平明显降低(P<0．01),NO含量明显升高(P< 0．01),FMD明显升高(P<0．05)。P组患者治疗后与C组相比,外周血中ox-LDL和CEC水平明显降低(P<0．01,P<0．05),NO明显升高(P<0．01),FMD明显升高(P<0．05)。C组CEC、NO含量及FMD含量治疗前后差异无统计学意义(P>0．05)。P组治疗后血浆ox-LDL与CEC呈正相关(r= 0．385,P<0．01),与NO FMD呈负相关(r=-0．517,P<0．01)。结论普罗布考具有抗氧化、降低ox-LDL,提高ACS患者血管内皮功能的作用。
Objective To observe the effect of probucol early treatment on vascular endothelial function in patients with acute coronary syndrome (ACS). Methods 49 ACS patients were randomly divided into two groups: probucol group (n = 24) and routine treatment group (n = 25). The levels of ox-LDL, Nitric oxide (NO) and circulating endothelial cells (CEC). The brachial artery endothelium-dependent vasodilatation (FMD) was measured by high-frequency ultrasound. The changes of indexes before and after treatment were observed for 3 months. Results Compared with those before treatment, the levels of ox-LDL and CEC in peripheral blood in P group were significantly decreased (P <0.01), the content of NO was significantly increased (P <0.01) <0.05). The levels of ox-LDL and CEC in peripheral blood in P group were significantly lower than those in C group (P <0.01, P <0.05), NO was significantly increased (P <0.01), FMD was significantly Increased (P <0.05). The CEC, NO content and FMD content in C group had no significant difference before and after treatment (P> 0.05). There was a positive correlation between plasma ox-LDL and CEC (P <0.01) in P group and negatively correlated with NO FMD (P <0.01). Conclusion Probucol has antioxidant, ox-LDL-lowering effects and enhances vascular endothelial function in patients with ACS.