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目的:寻找更加适合我国盐酸平阳霉素的同族杂质组分的检查方法。方法:通过对我国药典盐酸平阳霉素中有关物质检查法与日本药局方中硫酸博莱霉素有关物质检查法进行对比研究。结果:中国药典中的高效液相色谱(HPLC)法测定盐酸平阳霉素有关杂质优于日本药典方法。结论:我国药典有关物质检查法更加适合盐酸平阳霉素的同族杂质组分的检查。
Objective: To find more suitable for our country Pingyangmycin impurity components of the family of inspection methods. Methods: By comparing the Chinese medicine pharmacopoeia Pingyangmycin hydrochloride in the relevant substances check method and Japanese Pharmacopoeia square bleomycin sulphate related substances inspection method. Results: The HPLC method of Chinese Pharmacopoeia was superior to the Japanese Pharmacopoeia in the determination of Pingyangmycin hydrochloride related impurities. Conclusion: The Chinese Pharmacopoeia-related substance test method is more suitable for the detection of the same impurity components of pingyangmycin hydrochloride.