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A rapid and efficient method for the synthesis of isoxazolo[5,4-d]pyrimidin-4(5H)-ones has been developed throughcyclocondensation of 5-aminoisoxazole-4-carboxamides with orthoesters under conventional heating and solvent-free microwaveirradiation with solid acid catalysis. In comparison, the reactions are faster and the yields are higher under microwave irradiation.?2008 A. Davoodnia. Published by Elsevier B.V. On behalf of Chinese Chemical Society. All rights reserved.Keywonts: lsoxazoio[5,4-d]pyrimidin-4(5H)-ones; Orthoesters; Microwave irradiation; Conventional heating1001-8417/＄-see front matter ? 2008 A. Davoodnia. Published by Elsevier B.V. On behalf of Chinese Chemical Society. All rights reserved.