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目的 :了解 Ig A肾病 (Ig A - N )与扁桃体免疫异常的关系。方法 :经肾穿刺活检确诊为 Ig A - N 31例 ,以慢性扁桃体炎 16例作对照。扁桃体切除术后运用 ABC方法对扁桃体组织进行免疫组化标记。结果 :两组扁桃体在 Ig A、Ig G的表达上存在明显的区别 ,Ig A- N患者的扁桃体组织内产生 Ig A的淋巴细胞数显著增加。结论 :Ig A-N患者存在着扁桃体免疫异常 ,切除扁桃体可预防抗原入侵 ,消除扁桃体来源的 Ig A,减少循环中的 Ig A免疫复合物形成 ,进一步使肾小球基底膜区的 Ig A免疫复合物沉积减少。
Objective: To understand the relationship between Ig A nephropathy (Ig A - N) and tonsil immunodeficiency. Methods: Thirty - one cases of Ig A - N confirmed by renal biopsy and 16 cases of chronic tonsillitis were used as controls. Tonsillectomy using ABC method of tonsil tissue immunohistochemistry. Results: There was a significant difference between the two groups in the expression of IgA and IgG. The number of IgA-producing lymphocytes in tonsil of IgA-N patients increased significantly. CONCLUSIONS: Ig AN patients have abnormal tonsil immunity, resection of tonsils prevents antigen invasion, depletes tonsil-derived IgA, reduces circulating IgA immune complex formation, and further activates IgA immune complexes in the glomerular basement membrane area Deposition decreased.